Drug interactions
Canagliflozin + Telmisartan-amlodipine
Severity: Moderate
Canagliflozin and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canagliflozin causes osmotic diuresis and mild volume reduction, which can add to the blood pressure lowering effect of telmisartan and amlodipine. Volume depletion with an ARB may increase the risk of acute kidney injury.
What this interaction means in plain words
Canagliflozin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin belongs to Endocrine; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive volume reduction and hypotension from SGLT2 inhibition combined with ARB-mediated efferent arteriolar dilation.
What to do
Assess volume status before starting canagliflozin and monitor blood pressure, creatinine and potassium. Reduce other antihypertensives or diuretics if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Canagliflozin
Frequently asked questions
Can I take Canagliflozin with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Canagliflozin and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Canagliflozin causes osmotic diuresis and mild volume reduction, which can add to the blood pressure lowering effect of telmisartan and amlodipine. Volume depletion with an ARB may increase the risk of acute kidney injury.
How serious is the interaction between Canagliflozin and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess volume status before starting canagliflozin and monitor blood pressure, creatinine and potassium. Reduce other antihypertensives or diuretics if hypotension occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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