Drug interactions
Canagliflozin-metformin + Carbamazepine
Severity: Moderate
Canagliflozin-metformin and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces UGT enzymes that metabolize canagliflozin, lowering its exposure and glucose-lowering effect. Glycemic control may deteriorate.
What this interaction means in plain words
Canagliflozin-metformin and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Carbamazepine belongs to Central Nervous System.
Why it happens
Induction of UGT-mediated glucuronidation increases canagliflozin clearance.
What to do
Monitor glycemic control and consider increasing canagliflozin to 300 mg daily if eGFR is above 60 and the 100 mg dose is tolerated. If eGFR is lower, consider a different antihyperglycemic agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Carbamazepine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces UGT enzymes that metabolize canagliflozin, lowering its exposure and glucose-lowering effect. Glycemic control may deteriorate.
How serious is the interaction between Canagliflozin-metformin and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control and consider increasing canagliflozin to 300 mg daily if eGFR is above 60 and the 100 mg dose is tolerated. If eGFR is lower, consider a different antihyperglycemic agent.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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