Drug interactions
Canagliflozin-metformin + Clomipramine
Severity: Minor
Canagliflozin-metformin and Clomipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as clomipramine have occasionally been linked to altered glycemic control and hypoglycemia in patients taking antidiabetic drugs. The effect is inconsistent and usually small with metformin-based regimens.
What this interaction means in plain words
Canagliflozin-metformin and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Clomipramine belongs to Central Nervous System.
Why it happens
Possible modest effects of tricyclics on glucose metabolism; the mechanism is not well established.
What to do
No routine adjustment is needed. Monitor blood glucose when starting or stopping clomipramine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Clomipramine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Clomipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as clomipramine have occasionally been linked to altered glycemic control and hypoglycemia in patients taking antidiabetic drugs. The effect is inconsistent and usually small with metformin-based regimens.
How serious is the interaction between Canagliflozin-metformin and Clomipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood glucose when starting or stopping clomipramine.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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