Drug interactions
Canagliflozin-metformin + Darunavir
Severity: Moderate
Canagliflozin-metformin and Darunavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Darunavir, usually boosted with ritonavir or cobicistat, has a lower metabolic effect than older agents but still warrants attention.
What this interaction means in plain words
Canagliflozin-metformin and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Darunavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose metabolism oppose the glucose-lowering drugs.
What to do
Monitor blood glucose and HbA1c after starting darunavir and intensify antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Darunavir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Darunavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the effectiveness of antidiabetic therapy. Darunavir, usually boosted with ritonavir or cobicistat, has a lower metabolic effect than older agents but still warrants attention.
How serious is the interaction between Canagliflozin-metformin and Darunavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting darunavir and intensify antidiabetic therapy if control worsens.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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