Drug interactions
Canagliflozin-metformin + Eplerenone
Severity: Moderate
Canagliflozin-metformin and Eplerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eplerenone is a potassium-sparing mineralocorticoid antagonist that can cause hyperkalemia. Canagliflozin may add slightly to potassium elevations, mainly in patients with kidney impairment.
What this interaction means in plain words
Canagliflozin-metformin and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Eplerenone belongs to Cardiovascular.
Why it happens
Mineralocorticoid receptor blockade reduces renal potassium excretion, with a possible additive effect from canagliflozin.
What to do
Monitor serum potassium and renal function at initiation and periodically thereafter, especially in diabetic or CKD patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Eplerenone?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Eplerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eplerenone is a potassium-sparing mineralocorticoid antagonist that can cause hyperkalemia. Canagliflozin may add slightly to potassium elevations, mainly in patients with kidney impairment.
How serious is the interaction between Canagliflozin-metformin and Eplerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function at initiation and periodically thereafter, especially in diabetic or CKD patients.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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