Drug interactions
Canagliflozin-metformin + Fluphenazine
Severity: Minor
Canagliflozin-metformin and Fluphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can cause hyperglycemia and reduce the effect of antidiabetic drugs, although fluphenazine is less metabolically active than newer antipsychotics.
What this interaction means in plain words
Canagliflozin-metformin and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Fluphenazine belongs to Central Nervous System.
Why it happens
Phenothiazines may reduce insulin secretion and sensitivity, opposing glucose lowering.
What to do
Monitor blood glucose when fluphenazine is started or stopped and adjust antidiabetic treatment as required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Canagliflozin-metformin with Fluphenazine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Fluphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics can cause hyperglycemia and reduce the effect of antidiabetic drugs, although fluphenazine is less metabolically active than newer antipsychotics.
How serious is the interaction between Canagliflozin-metformin and Fluphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when fluphenazine is started or stopped and adjust antidiabetic treatment as required.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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