Drug interactions
Canagliflozin-metformin + Furosemide
Severity: Moderate
Canagliflozin-metformin and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide may raise metformin concentrations, and loop diuretics can impair glucose tolerance. Volume depletion from the diuretic, especially combined with canagliflozin's diuretic effect, may reduce renal function and raise the risk of metformin accumulation.
What this interaction means in plain words
Canagliflozin-metformin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Furosemide belongs to Cardiovascular.
Why it happens
Pharmacokinetic increase in metformin exposure plus diuretic-induced volume depletion and mild hyperglycemic effects of furosemide.
What to do
Monitor renal function, hydration status and blood glucose, and adjust the doses of the diabetes drugs if volume depletion or renal impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Canagliflozin-metformin with Furosemide?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide may raise metformin concentrations, and loop diuretics can impair glucose tolerance. Volume depletion from the diuretic, especially combined with canagliflozin's diuretic effect, may reduce renal function and raise the risk of metformin accumulation.
How serious is the interaction between Canagliflozin-metformin and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hydration status and blood glucose, and adjust the doses of the diabetes drugs if volume depletion or renal impairment develops.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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