Drug interactions
Canagliflozin-metformin + Iloperidone
Severity: Moderate
Canagliflozin-metformin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone, like other atypical antipsychotics, can cause hyperglycemia and impair glycemic control. In a patient taking canagliflozin-metformin, glucose control may worsen after the antipsychotic is started.
What this interaction means in plain words
Canagliflozin-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics can promote insulin resistance and reduce insulin secretion, opposing the glucose-lowering effect of the antidiabetic drugs.
What to do
Check fasting glucose and HbA1c when iloperidone is started and at regular intervals afterwards. Adjust the antidiabetic regimen if control deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Canagliflozin-metformin with Iloperidone?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone, like other atypical antipsychotics, can cause hyperglycemia and impair glycemic control. In a patient taking canagliflozin-metformin, glucose control may worsen after the antipsychotic is started.
How serious is the interaction between Canagliflozin-metformin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c when iloperidone is started and at regular intervals afterwards. Adjust the antidiabetic regimen if control deteriorates.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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