Drug interactions
Canagliflozin-metformin + Imidapril
Severity: Moderate
Canagliflozin-metformin and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and occasionally lower blood glucose in people with diabetes. They can also reduce renal function or cause volume depletion, which together with canagliflozin may raise metformin accumulation and lactic acidosis risk.
What this interaction means in plain words
Canagliflozin-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Imidapril belongs to Cardiovascular.
Why it happens
ACE inhibition can improve insulin sensitivity and reduce glomerular filtration, particularly alongside SGLT2-inhibitor-related volume loss, which reduces renal metformin clearance.
What to do
Monitor blood glucose, serum creatinine/eGFR and volume status after starting or adjusting imidapril. Reduce or stop metformin if eGFR falls substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Canagliflozin-metformin with Imidapril?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and occasionally lower blood glucose in people with diabetes. They can also reduce renal function or cause volume depletion, which together with canagliflozin may raise metformin accumulation and lactic acidosis risk.
How serious is the interaction between Canagliflozin-metformin and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose, serum creatinine/eGFR and volume status after starting or adjusting imidapril. Reduce or stop metformin if eGFR falls substantially.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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