Drug interactions
Canagliflozin-metformin + Insulin glargine
Severity: Moderate
Canagliflozin-metformin and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with canagliflozin and metformin gives additive glucose lowering and raises the risk of hypoglycemia. The risk is greatest when insulin doses are not reduced as glycemic control improves.
What this interaction means in plain words
Canagliflozin-metformin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering through insulin-dependent and insulin-independent pathways (renal glucose excretion, reduced hepatic glucose output).
What to do
Monitor blood glucose closely when starting the combination and consider reducing the basal insulin dose. Educate the patient on recognizing hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Insulin glargine
Frequently asked questions
Can I take Canagliflozin-metformin with Insulin glargine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with canagliflozin and metformin gives additive glucose lowering and raises the risk of hypoglycemia. The risk is greatest when insulin doses are not reduced as glycemic control improves.
How serious is the interaction between Canagliflozin-metformin and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting the combination and consider reducing the basal insulin dose. Educate the patient on recognizing hypoglycemia.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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