Drug interactions
Canagliflozin-metformin + Letermovir
Severity: Minor
Canagliflozin-metformin and Letermovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir may modestly increase canagliflozin exposure, which could strengthen its glucose-lowering and diuretic effects. The clinical effect is expected to be small.
What this interaction means in plain words
Canagliflozin-metformin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits OATP1B1/3 and UGT-mediated pathways, which may modestly raise canagliflozin concentrations; the mechanism is not fully characterized.
What to do
No dose change is usually required. Monitor glucose and volume status during letermovir therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Canagliflozin-metformin with Letermovir?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Letermovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Letermovir may modestly increase canagliflozin exposure, which could strengthen its glucose-lowering and diuretic effects. The clinical effect is expected to be small.
How serious is the interaction between Canagliflozin-metformin and Letermovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required. Monitor glucose and volume status during letermovir therapy.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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