Drug interactions
Canagliflozin-metformin + Memantine
Severity: Minor
Canagliflozin-metformin and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated partly by renal tubular secretion through cationic pathways and could theoretically compete with metformin. Clinically meaningful changes in metformin levels have not been well documented.
What this interaction means in plain words
Canagliflozin-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Memantine belongs to Central Nervous System.
Why it happens
Theoretical competition for renal tubular cationic transporters, reducing metformin clearance.
What to do
No routine adjustment is needed; monitor renal function and glycemic response in elderly patients or those with reduced kidney function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Memantine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Memantine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated partly by renal tubular secretion through cationic pathways and could theoretically compete with metformin. Clinically meaningful changes in metformin levels have not been well documented.
How serious is the interaction between Canagliflozin-metformin and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and glycemic response in elderly patients or those with reduced kidney function.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
