Drug interactions
Canagliflozin-metformin + Moxifloxacin
Severity: Moderate
Canagliflozin-metformin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients with diabetes taking glucose-lowering drugs. Moxifloxacin carries a lower risk than some other agents in the class, but disturbances can still occur.
What this interaction means in plain words
Canagliflozin-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release, causing dysglycemia that is additive to the antidiabetic drugs.
What to do
Monitor blood glucose closely during the antibiotic course and educate the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and switch if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Moxifloxacin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both hypoglycemia and hyperglycemia in patients with diabetes taking glucose-lowering drugs. Moxifloxacin carries a lower risk than some other agents in the class, but disturbances can still occur.
How serious is the interaction between Canagliflozin-metformin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and educate the patient on symptoms of hypo- and hyperglycemia. Stop the fluoroquinolone and switch if significant dysglycemia occurs.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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