Drug interactions
Canagliflozin-metformin + Perphenazine
Severity: Minor
Canagliflozin-metformin and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics can cause hyperglycemia and weight gain. This may reduce the glycemic effect of canagliflozin-metformin.
What this interaction means in plain words
Canagliflozin-metformin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Antipsychotic-induced reduction in insulin sensitivity and secretion opposes antidiabetic effects.
What to do
Monitor blood glucose after starting or stopping perphenazine and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Canagliflozin-metformin with Perphenazine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazine antipsychotics can cause hyperglycemia and weight gain. This may reduce the glycemic effect of canagliflozin-metformin.
How serious is the interaction between Canagliflozin-metformin and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping perphenazine and adjust the antidiabetic regimen as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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