Drug interactions
Canagliflozin-metformin + Sirolimus
Severity: Moderate
Canagliflozin-metformin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus is associated with hyperglycemia, insulin resistance and new-onset diabetes, which may offset the glucose-lowering effect of metformin and canagliflozin. Transplant patients may also have renal impairment that affects the safety of both antidiabetic components.
What this interaction means in plain words
Canagliflozin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
Sirolimus impairs insulin signaling and beta-cell function through mTOR inhibition, opposing the effect of antidiabetic agents.
What to do
Monitor glucose and HbA1c and adjust antidiabetic therapy as needed. Monitor renal function and review the continued suitability of metformin and canagliflozin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Sirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Sirolimus?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus is associated with hyperglycemia, insulin resistance and new-onset diabetes, which may offset the glucose-lowering effect of metformin and canagliflozin. Transplant patients may also have renal impairment that affects the safety of both antidiabetic components.
How serious is the interaction between Canagliflozin-metformin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c and adjust antidiabetic therapy as needed. Monitor renal function and review the continued suitability of metformin and canagliflozin.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
