Drug interactions
Canagliflozin-metformin + Vorinostat
Severity: Minor
Canagliflozin-metformin and Vorinostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with hyperglycemia, which could oppose the effects of antidiabetic therapy. Glycemic control may deteriorate during treatment.
What this interaction means in plain words
Canagliflozin-metformin and Vorinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Vorinostat belongs to Oncology.
Why it happens
Pharmacodynamic antagonism through drug-related hyperglycemia; mechanism not firmly established.
What to do
Monitor blood glucose during vorinostat therapy and adjust antidiabetic treatment as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Canagliflozin-metformin with Vorinostat?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Vorinostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vorinostat has been associated with hyperglycemia, which could oppose the effects of antidiabetic therapy. Glycemic control may deteriorate during treatment.
How serious is the interaction between Canagliflozin-metformin and Vorinostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during vorinostat therapy and adjust antidiabetic treatment as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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