Drug interactions
Canakinumab + Pneumococcal vaccine 13-valent
Severity: Minor
Canakinumab and Pneumococcal vaccine 13-valent: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Canakinumab blocks interleukin-1 beta and may modestly blunt immune responses, but studies of inactivated vaccines in treated patients showed adequate antibody responses. The conjugate pneumococcal vaccine is non-live, so the contraindication stated for live vaccines does not apply. Any reduction in protection is likely small.
What this interaction means in plain words
Canakinumab and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canakinumab belongs to Miscellaneous; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Immunomodulation through IL-1 beta blockade may theoretically reduce vaccine immunogenicity, though this is not well established.
What to do
Give the pneumococcal conjugate vaccine as indicated, ideally before starting canakinumab where feasible. Live vaccines should still be avoided during treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Canakinumab
- Adalimumab + Canakinumab Major
- Anakinra + Canakinumab Major
- Baricitinib + Canakinumab Major
- Basiliximab + Canakinumab Major
- Canakinumab + Etanercept Major
- Canakinumab + Golimumab Major
Frequently asked questions
Can I take Canakinumab with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as minor. Canakinumab and Pneumococcal vaccine 13-valent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Canakinumab blocks interleukin-1 beta and may modestly blunt immune responses, but studies of inactivated vaccines in treated patients showed adequate antibody responses. The conjugate pneumococcal vaccine is non-live, so the contraindication stated for live vaccines does not apply. Any reduction in protection is likely small.
How serious is the interaction between Canakinumab and Pneumococcal vaccine 13-valent?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the pneumococcal conjugate vaccine as indicated, ideally before starting canakinumab where feasible. Live vaccines should still be avoided during treatment.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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