Drug interactions
Candesartan + Dalteparin
Severity: Moderate
Candesartan and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparins can suppress adrenal aldosterone production, which may cause hyperkalemia. Combined with an ARB, which also lowers aldosterone effect, the risk of elevated potassium increases, notably in diabetes, renal impairment or prolonged use.
What this interaction means in plain words
Candesartan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Dalteparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis adds to ARB blockade of angiotensin II-driven aldosterone effects.
What to do
Monitor serum potassium, especially if therapy continues beyond several days or renal function is reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Candesartan with Dalteparin?
MediHelp rates the interaction as moderate. Candesartan and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparins can suppress adrenal aldosterone production, which may cause hyperkalemia. Combined with an ARB, which also lowers aldosterone effect, the risk of elevated potassium increases, notably in diabetes, renal impairment or prolonged use.
How serious is the interaction between Candesartan and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially if therapy continues beyond several days or renal function is reduced.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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