Drug interactions
Candesartan + Eplerenone
Severity: Major
Candesartan and Eplerenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers reduce aldosterone effects and eplerenone blocks the mineralocorticoid receptor, increasing hyperkalemia risk. Risk is highest with renal impairment or diabetes.
What this interaction means in plain words
Candesartan and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan belongs to Cardiovascular; Eplerenone belongs to Cardiovascular.
Why it happens
Additive inhibition of the renin-angiotensin-aldosterone system, reducing renal potassium excretion.
What to do
Monitor potassium and creatinine at baseline, early after initiation, and regularly. Avoid potassium supplements and reduce or stop one drug if hyperkalemia occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eplerenone
- Amiloride + Eplerenone Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Clarithromycin + Eplerenone Contraindicated
- Cobicistat + Eplerenone Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Eplerenone Contraindicated
- Ensitrelvir + Eplerenone Contraindicated
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Eplerenone?
MediHelp rates the interaction as major. Candesartan and Eplerenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Angiotensin receptor blockers reduce aldosterone effects and eplerenone blocks the mineralocorticoid receptor, increasing hyperkalemia risk. Risk is highest with renal impairment or diabetes.
How serious is the interaction between Candesartan and Eplerenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and creatinine at baseline, early after initiation, and regularly. Avoid potassium supplements and reduce or stop one drug if hyperkalemia occurs.
What other medicines interact with Eplerenone?
MediHelp also lists interactions of Eplerenone with, for example, Amiloride, Atazanavir, Clarithromycin. The full list is on the Eplerenone page.
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