Drug interactions
Candesartan + Esmolol
Severity: Moderate
Candesartan and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and candesartan both lower blood pressure, and the combination can cause additive hypotension. Candesartan may raise serum potassium, and it is harmful in pregnancy.
What this interaction means in plain words
Candesartan and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects of beta-blockade and angiotensin receptor blockade, with ARB-related potassium retention.
What to do
Monitor blood pressure and, with continued ARB therapy, serum potassium and renal function. Avoid candesartan in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Esmolol?
MediHelp rates the interaction as moderate. Candesartan and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol and candesartan both lower blood pressure, and the combination can cause additive hypotension. Candesartan may raise serum potassium, and it is harmful in pregnancy.
How serious is the interaction between Candesartan and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and, with continued ARB therapy, serum potassium and renal function. Avoid candesartan in pregnancy.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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