Drug interactions
Candesartan + Ethacrynic acid
Severity: Moderate
Candesartan and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics add to candesartan's blood pressure lowering and may cause volume depletion, hypotension and renal impairment, especially at initiation. Potassium effects tend to offset each other.
What this interaction means in plain words
Candesartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects of diuresis-related volume depletion and angiotensin receptor blockade, with opposing effects on potassium.
What to do
Monitor blood pressure, renal function and electrolytes after starting or changing doses; consider lowering the diuretic dose when starting candesartan in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Candesartan with Ethacrynic acid?
MediHelp rates the interaction as moderate. Candesartan and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics add to candesartan's blood pressure lowering and may cause volume depletion, hypotension and renal impairment, especially at initiation. Potassium effects tend to offset each other.
How serious is the interaction between Candesartan and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or changing doses; consider lowering the diuretic dose when starting candesartan in volume-depleted patients.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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