Drug interactions
Candesartan + Furosemide
Severity: Moderate
Candesartan and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can cause volume depletion that makes blood pressure and renal perfusion dependent on angiotensin II, so adding candesartan may cause hypotension and a decline in renal function. The potassium effects partly offset each other, but the net change is unpredictable.
What this interaction means in plain words
Candesartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Furosemide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects: diuretic-induced volume depletion plus angiotensin receptor blockade lowers glomerular filtration pressure and blood pressure, while potassium effects oppose.
What to do
Monitor blood pressure, serum creatinine and potassium after initiation or dose change. Consider reducing the diuretic dose when starting candesartan in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Furosemide?
MediHelp rates the interaction as moderate. Candesartan and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can cause volume depletion that makes blood pressure and renal perfusion dependent on angiotensin II, so adding candesartan may cause hypotension and a decline in renal function. The potassium effects partly offset each other, but the net change is unpredictable.
How serious is the interaction between Candesartan and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after initiation or dose change. Consider reducing the diuretic dose when starting candesartan in volume-depleted patients.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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