Drug interactions
Candesartan + Nabumetone
Severity: Moderate
Candesartan and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nabumetone can weaken the antihypertensive effect of candesartan and increase the risk of renal function deterioration, especially in elderly or volume-depleted patients. Hyperkalemia can also occur.
What this interaction means in plain words
Candesartan and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion and promotes sodium retention, compounding the effect of angiotensin receptor blockade on glomerular filtration and potassium excretion.
What to do
Ensure adequate hydration and check blood pressure, serum creatinine and potassium within the first weeks of combined use. Avoid or limit the NSAID in patients with renal impairment or volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Nabumetone?
MediHelp rates the interaction as moderate. Candesartan and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nabumetone can weaken the antihypertensive effect of candesartan and increase the risk of renal function deterioration, especially in elderly or volume-depleted patients. Hyperkalemia can also occur.
How serious is the interaction between Candesartan and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check blood pressure, serum creatinine and potassium within the first weeks of combined use. Avoid or limit the NSAID in patients with renal impairment or volume depletion.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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