Drug interactions
Candesartan + Tizanidine
Severity: Moderate
Candesartan and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine lowers blood pressure through central alpha-2 stimulation, and candesartan lowers it by blocking angiotensin II receptors. Together they can produce additive hypotension, with dizziness or fainting, particularly on starting therapy or after dose increases.
What this interaction means in plain words
Candesartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive antihypertensive effects from central alpha-2 agonism and angiotensin II receptor blockade.
What to do
Monitor blood pressure, especially when starting or titrating tizanidine, and adjust the antihypertensive regimen if symptomatic hypotension occurs. Advise patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Tizanidine?
MediHelp rates the interaction as moderate. Candesartan and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine lowers blood pressure through central alpha-2 stimulation, and candesartan lowers it by blocking angiotensin II receptors. Together they can produce additive hypotension, with dizziness or fainting, particularly on starting therapy or after dose increases.
How serious is the interaction between Candesartan and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, especially when starting or titrating tizanidine, and adjust the antihypertensive regimen if symptomatic hypotension occurs. Advise patients to rise slowly.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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