Drug interactions
Candesartan-hydrochlorothiazide + Celecoxib
Severity: Moderate
Candesartan-hydrochlorothiazide and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib can reduce the antihypertensive effect of candesartan and hydrochlorothiazide. Together with an ARB and a diuretic, NSAIDs raise the risk of acute kidney injury and hyperkalemia, particularly in elderly or dehydrated patients.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, which opposes ARB and diuretic effects.
What to do
Use the lowest effective NSAID dose for the shortest duration and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Celecoxib?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib can reduce the antihypertensive effect of candesartan and hydrochlorothiazide. Together with an ARB and a diuretic, NSAIDs raise the risk of acute kidney injury and hyperkalemia, particularly in elderly or dehydrated patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest duration and ensure adequate hydration. Monitor blood pressure, serum creatinine and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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