Drug interactions
Candesartan-hydrochlorothiazide + Cholestyramine
Severity: Moderate
Candesartan-hydrochlorothiazide and Cholestyramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds hydrochlorothiazide in the gut and significantly reduces its absorption. This can weaken the diuretic and antihypertensive effect.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Cholestyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Cholestyramine belongs to Cardiovascular.
Why it happens
Anion-exchange resin binds hydrochlorothiazide in the gastrointestinal tract and reduces absorption.
What to do
Take the hydrochlorothiazide-containing product at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Cholestyramine
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Cholestyramine?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Cholestyramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds hydrochlorothiazide in the gut and significantly reduces its absorption. This can weaken the diuretic and antihypertensive effect.
How serious is the interaction between Candesartan-hydrochlorothiazide and Cholestyramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the hydrochlorothiazide-containing product at least 4 hours before or 4 to 6 hours after cholestyramine. Monitor blood pressure.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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