Drug interactions
Candesartan-hydrochlorothiazide + Etodolac
Severity: Major
Candesartan-hydrochlorothiazide and Etodolac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of candesartan and hydrochlorothiazide. With an ARB and a diuretic, this also raises the risk of acute kidney injury, especially in older or volume-depleted patients, and may cause hyperkalemia.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of vasodilatory prostaglandins reduces glomerular perfusion and sodium excretion, which counteracts antihypertensive therapy and adds to renal hemodynamic stress from RAAS blockade and diuresis.
What to do
Avoid regular NSAID use where possible, or use the lowest dose for the shortest time. Ensure adequate hydration and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Etodolac?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs reduce renal prostaglandin synthesis, which can blunt the antihypertensive effect of candesartan and hydrochlorothiazide. With an ARB and a diuretic, this also raises the risk of acute kidney injury, especially in older or volume-depleted patients, and may cause hyperkalemia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular NSAID use where possible, or use the lowest dose for the shortest time. Ensure adequate hydration and monitor blood pressure, creatinine and potassium.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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