Drug interactions
Candesartan-hydrochlorothiazide + Methoxsalen
Severity: Moderate
Candesartan-hydrochlorothiazide and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide is a known photosensitizing drug, and methoxsalen is a potent photosensitizer used with UVA exposure. Concurrent use may increase the risk of severe phototoxic reactions such as burns.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Methoxsalen belongs to Anti Fungals.
Why it happens
Additive photosensitization from two agents that increase skin sensitivity to ultraviolet light.
What to do
Use strict photoprotection and consider adjusting UVA dosing. Monitor the skin for erythema or burns after treatment sessions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Methoxsalen?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide is a known photosensitizing drug, and methoxsalen is a potent photosensitizer used with UVA exposure. Concurrent use may increase the risk of severe phototoxic reactions such as burns.
How serious is the interaction between Candesartan-hydrochlorothiazide and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use strict photoprotection and consider adjusting UVA dosing. Monitor the skin for erythema or burns after treatment sessions.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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