Drug interactions
Candesartan-hydrochlorothiazide + Oliceridine
Severity: Minor
Candesartan-hydrochlorothiazide and Oliceridine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can reduce diuretic effectiveness through antidiuretic hormone release, and may also cause hypotension. Oliceridine could therefore blunt diuresis or add to blood pressure lowering with candesartan and hydrochlorothiazide.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Oliceridine belongs to Musculoskeletal.
Why it happens
Opioid-induced antidiuretic hormone release and additive hypotensive effects.
What to do
Monitor blood pressure, fluid status and electrolytes during oliceridine use and adjust diuretic dosing if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Oliceridine?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Oliceridine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can reduce diuretic effectiveness through antidiuretic hormone release, and may also cause hypotension. Oliceridine could therefore blunt diuresis or add to blood pressure lowering with candesartan and hydrochlorothiazide.
How serious is the interaction between Candesartan-hydrochlorothiazide and Oliceridine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and electrolytes during oliceridine use and adjust diuretic dosing if needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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