Drug interactions
Candesartan-hydrochlorothiazide + Pivmecillinam
Severity: Minor
Candesartan-hydrochlorothiazide and Pivmecillinam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazides may slightly reduce the renal excretion of mecillinam, the active form of pivmecillinam. Clinical significance is minimal given the broad safety margin of penicillins.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Pivmecillinam belongs to Anti Bacterial.
Why it happens
Possible competition for renal tubular secretion reduces mecillinam clearance.
What to do
No routine adjustment is needed beyond awareness in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Pivmecillinam
- Doxycycline + Pivmecillinam Moderate
- Minocycline + Pivmecillinam Moderate
- Pivmecillinam + Probenecid Moderate
- Pivmecillinam + Tetracycline Moderate
- Acetylsalicylic acid + Pivmecillinam Minor
- Acyclovir + Pivmecillinam Minor
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Pivmecillinam?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Pivmecillinam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazides may slightly reduce the renal excretion of mecillinam, the active form of pivmecillinam. Clinical significance is minimal given the broad safety margin of penicillins.
How serious is the interaction between Candesartan-hydrochlorothiazide and Pivmecillinam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed beyond awareness in patients with renal impairment.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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