Drug interactions
Candesartan-hydrochlorothiazide + Probenecid
Severity: Minor
Candesartan-hydrochlorothiazide and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide competes with probenecid for organic anion transport in the kidney and raises serum uric acid, which opposes the uricosuric action of probenecid. Probenecid may also reduce renal clearance of hydrochlorothiazide.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Probenecid belongs to Genitourinary.
Why it happens
Competition for renal tubular organic anion secretion, plus thiazide-induced urate retention that counteracts uricosuric effect.
What to do
Monitor serum uric acid and gout control, and increase the probenecid dose if needed. Consider an alternative antihypertensive in patients with difficult gout.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Probenecid?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide competes with probenecid for organic anion transport in the kidney and raises serum uric acid, which opposes the uricosuric action of probenecid. Probenecid may also reduce renal clearance of hydrochlorothiazide.
How serious is the interaction between Candesartan-hydrochlorothiazide and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum uric acid and gout control, and increase the probenecid dose if needed. Consider an alternative antihypertensive in patients with difficult gout.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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