Drug interactions
Candesartan-hydrochlorothiazide + Quinidine
Severity: Moderate
Candesartan-hydrochlorothiazide and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a basic drug that is secreted by renal tubular cation transport and may compete with hydrochlorothiazide for tubular secretion. This could modestly raise hydrochlorothiazide exposure, but the clinical effect is generally small. Quinidine also has its own arrhythmia risk that is increased if the thiazide causes hypokalemia or hypomagnesemia.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Possible competition for renal tubular secretion, plus thiazide-induced hypokalemia that increases quinidine-related QT prolongation risk.
What to do
Monitor serum potassium and magnesium and correct deficits promptly. Check ECG/QTc if other QT-prolonging factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Quinidine?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a basic drug that is secreted by renal tubular cation transport and may compete with hydrochlorothiazide for tubular secretion. This could modestly raise hydrochlorothiazide exposure, but the clinical effect is generally small. Quinidine also has its own arrhythmia risk that is increased if the thiazide causes hypokalemia or hypomagnesemia.
How serious is the interaction between Candesartan-hydrochlorothiazide and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits promptly. Check ECG/QTc if other QT-prolonging factors are present.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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