Drug interactions
Candesartan-hydrochlorothiazide + Repaglinide
Severity: Minor
Candesartan-hydrochlorothiazide and Repaglinide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and may blunt the effect of antidiabetic drugs such as repaglinide. The effect is dose related and usually modest with low-dose hydrochlorothiazide.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Repaglinide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through thiazide-induced impaired insulin secretion and reduced insulin sensitivity, partly mediated by hypokalemia.
What to do
Monitor blood glucose when starting or adjusting the thiazide and adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Repaglinide?
MediHelp rates the interaction as minor. Candesartan-hydrochlorothiazide and Repaglinide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and may blunt the effect of antidiabetic drugs such as repaglinide. The effect is dose related and usually modest with low-dose hydrochlorothiazide.
How serious is the interaction between Candesartan-hydrochlorothiazide and Repaglinide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or adjusting the thiazide and adjust the antidiabetic regimen if control worsens.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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