Drug interactions
Candesartan-hydrochlorothiazide + Treprostinil
Severity: Moderate
Candesartan-hydrochlorothiazide and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a vasodilator and can enhance the blood pressure lowering of candesartan and hydrochlorothiazide, with a risk of symptomatic hypotension.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation and blood pressure reduction.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating treprostinil, and reduce antihypertensive doses if required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Treprostinil?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a vasodilator and can enhance the blood pressure lowering of candesartan and hydrochlorothiazide, with a risk of symptomatic hypotension.
How serious is the interaction between Candesartan-hydrochlorothiazide and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating treprostinil, and reduce antihypertensive doses if required.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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