Drug interactions
Candesartan-hydrochlorothiazide + Voclosporin
Severity: Moderate
Candesartan-hydrochlorothiazide and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, can cause nephrotoxicity and hyperkalemia. Combined with an angiotensin receptor blocker, the effects on glomerular hemodynamics and potassium handling can worsen renal function and raise serum potassium. Thiazide-related volume depletion may add to the renal risk.
What this interaction means in plain words
Candesartan-hydrochlorothiazide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Voclosporin belongs to Miscellaneous.
Why it happens
Additive effects on renal hemodynamics and reduced potassium excretion from calcineurin inhibition and angiotensin II receptor blockade.
What to do
Monitor serum potassium, creatinine and eGFR regularly, particularly after starting or changing doses. Reduce or interrupt voclosporin according to labeling if renal function declines or hyperkalemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Acemetacin + Candesartan-hydrochlorothiazide Major
- Amifostine + Candesartan-hydrochlorothiazide Major
- Amiloride + Candesartan-hydrochlorothiazide Major
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Candesartan-hydrochlorothiazide with Voclosporin?
MediHelp rates the interaction as moderate. Candesartan-hydrochlorothiazide and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin, a calcineurin inhibitor, can cause nephrotoxicity and hyperkalemia. Combined with an angiotensin receptor blocker, the effects on glomerular hemodynamics and potassium handling can worsen renal function and raise serum potassium. Thiazide-related volume depletion may add to the renal risk.
How serious is the interaction between Candesartan-hydrochlorothiazide and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine and eGFR regularly, particularly after starting or changing doses. Reduce or interrupt voclosporin according to labeling if renal function declines or hyperkalemia develops.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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