Drug interactions
Cannabidiol + Carbamazepine
Severity: Moderate
Cannabidiol and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine lowers cannabidiol concentrations, potentially reducing seizure control. Cannabidiol may also affect carbamazepine levels.
What this interaction means in plain words
Cannabidiol and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Carbamazepine belongs to Central Nervous System.
Why it happens
Carbamazepine induces CYP3A4 (and CYP2C19), increasing cannabidiol clearance.
What to do
Consider increasing the cannabidiol dose based on response and tolerability, and monitor seizure frequency and carbamazepine levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Carbamazepine?
MediHelp rates the interaction as moderate. Cannabidiol and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine lowers cannabidiol concentrations, potentially reducing seizure control. Cannabidiol may also affect carbamazepine levels.
How serious is the interaction between Cannabidiol and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider increasing the cannabidiol dose based on response and tolerability, and monitor seizure frequency and carbamazepine levels.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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