Drug interactions
Cannabidiol + Clobazam
Severity: Moderate
Cannabidiol and Clobazam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol raises concentrations of the active metabolite N-desmethylclobazam, which can intensify sedation and somnolence. The effect is well documented in patients with epilepsy.
What this interaction means in plain words
Cannabidiol and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clobazam belongs to Central Nervous System.
Why it happens
Inhibition of CYP2C19 by cannabidiol reduces N-desmethylclobazam metabolism.
What to do
Monitor for sedation, drowsiness and reduced alertness. Reduce the clobazam dose if adverse reactions develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Other interactions of Clobazam
- Amobarbital + Clobazam Major
- Buprenorphine + Clobazam Major
- Butorphanol + Clobazam Major
- Carisoprodol + Clobazam Major
- Chloral hydrate + Clobazam Major
- Clobazam + Clozapine Major
Frequently asked questions
Can I take Cannabidiol with Clobazam?
MediHelp rates the interaction as moderate. Cannabidiol and Clobazam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol raises concentrations of the active metabolite N-desmethylclobazam, which can intensify sedation and somnolence. The effect is well documented in patients with epilepsy.
How serious is the interaction between Cannabidiol and Clobazam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, drowsiness and reduced alertness. Reduce the clobazam dose if adverse reactions develop.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Sodium valproate, Tacrolimus. The full list is on the Cannabidiol page.
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