Drug interactions
Cannabidiol + Crizotinib
Severity: Minor
Cannabidiol and Crizotinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crizotinib may increase cannabidiol exposure by inhibiting CYP3A4, which could increase somnolence, sedation and liver enzyme elevations.
What this interaction means in plain words
Cannabidiol and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Crizotinib belongs to Oncology.
Why it happens
Crizotinib inhibits CYP3A4, one of the pathways metabolizing cannabidiol.
What to do
Monitor for sedation and adverse effects and reduce the cannabidiol dose if these occur. Check liver enzymes periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Crizotinib
- Crizotinib + Flibanserin Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Crizotinib + Lonafarnib Contraindicated
- Crizotinib + Pimozide Contraindicated
- Crizotinib + Saquinavir Contraindicated
- Crizotinib + Thioridazine Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Crizotinib?
MediHelp rates the interaction as minor. Cannabidiol and Crizotinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crizotinib may increase cannabidiol exposure by inhibiting CYP3A4, which could increase somnolence, sedation and liver enzyme elevations.
How serious is the interaction between Cannabidiol and Crizotinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and adverse effects and reduce the cannabidiol dose if these occur. Check liver enzymes periodically.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Lonafarnib. The full list is on the Crizotinib page.
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