Drug interactions
Cannabidiol + Flibanserin
Severity: Moderate
Cannabidiol and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, which contributes to flibanserin metabolism, so flibanserin exposure may rise. Higher levels could increase sedation, dizziness, and hypotension.
What this interaction means in plain words
Cannabidiol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Flibanserin belongs to Genitourinary.
Why it happens
Inhibition of CYP2C19 reduces flibanserin clearance; cannabidiol also adds CNS depression.
What to do
Monitor for sedation, dizziness and low blood pressure; consider reducing flibanserin or avoiding the combination if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Flibanserin?
MediHelp rates the interaction as moderate. Cannabidiol and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19, which contributes to flibanserin metabolism, so flibanserin exposure may rise. Higher levels could increase sedation, dizziness, and hypotension.
How serious is the interaction between Cannabidiol and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and low blood pressure; consider reducing flibanserin or avoiding the combination if adverse effects occur.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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