Drug interactions
Cannabidiol + Haloperidol
Severity: Minor
Cannabidiol and Haloperidol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may be affected by CYP3A4 inhibition, but haloperidol is at most a weak CYP3A4 inhibitor, so any rise in cannabidiol exposure is uncertain. Both drugs also cause sedation, which may be additive.
What this interaction means in plain words
Cannabidiol and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Possible minor CYP3A4 inhibition plus additive CNS depression.
What to do
Monitor for excessive sedation and adverse effects of cannabidiol; reduce the dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Haloperidol?
MediHelp rates the interaction as minor. Cannabidiol and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may be affected by CYP3A4 inhibition, but haloperidol is at most a weak CYP3A4 inhibitor, so any rise in cannabidiol exposure is uncertain. Both drugs also cause sedation, which may be additive.
How serious is the interaction between Cannabidiol and Haloperidol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and adverse effects of cannabidiol; reduce the dose if these occur.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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