Drug interactions
Cannabidiol + Isotretinoin
Severity: Minor
Cannabidiol and Isotretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C8, which participates in isotretinoin metabolism. Isotretinoin exposure could increase, potentially intensifying dose-related adverse effects such as dryness, hypertriglyceridemia and hepatic enzyme elevation.
What this interaction means in plain words
Cannabidiol and Isotretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Isotretinoin belongs to Dermatology.
Why it happens
Possible inhibition of CYP2C8-mediated isotretinoin metabolism by cannabidiol.
What to do
Monitor for isotretinoin adverse effects and consider checking lipids and liver enzymes; reduce the isotretinoin dose if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isotretinoin
- Demeclocycline + Isotretinoin Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Isotretinoin + Oxytetracycline Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Aminolevulinic acid + Isotretinoin Major
- Doxycycline + Isotretinoin Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Isotretinoin?
MediHelp rates the interaction as minor. Cannabidiol and Isotretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may inhibit CYP2C8, which participates in isotretinoin metabolism. Isotretinoin exposure could increase, potentially intensifying dose-related adverse effects such as dryness, hypertriglyceridemia and hepatic enzyme elevation.
How serious is the interaction between Cannabidiol and Isotretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for isotretinoin adverse effects and consider checking lipids and liver enzymes; reduce the isotretinoin dose if toxicity appears.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.
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