Drug interactions
Cannabidiol + Omeprazole
Severity: Moderate
Cannabidiol and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and can raise omeprazole levels, and omeprazole may in turn raise levels of cannabidiol. Effects are usually modest but may increase adverse effects of either drug.
What this interaction means in plain words
Cannabidiol and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Mutual CYP2C19 inhibition reduces metabolism of both drugs.
What to do
Monitor for cannabidiol adverse effects such as sedation and transaminase elevation. Reduce the dose of either drug if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Omeprazole?
MediHelp rates the interaction as moderate. Cannabidiol and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19 and can raise omeprazole levels, and omeprazole may in turn raise levels of cannabidiol. Effects are usually modest but may increase adverse effects of either drug.
How serious is the interaction between Cannabidiol and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cannabidiol adverse effects such as sedation and transaminase elevation. Reduce the dose of either drug if needed.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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