Drug interactions
Cannabidiol + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Minor
Cannabidiol and Sofosbuvir-velpatasvir-voxilaprevir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can inhibit several CYP enzymes and may modestly raise exposure to velpatasvir and voxilaprevir. The expected clinical effect is small, but exposure to the antivirals could increase slightly.
What this interaction means in plain words
Cannabidiol and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Cannabidiol may inhibit CYP2C8 and other CYP enzymes involved in velpatasvir and voxilaprevir metabolism, a prediction that is largely theoretical.
What to do
No routine dose change is needed. Monitor for adverse effects of the antiviral combination such as headache, fatigue and gastrointestinal upset, and for liver enzyme changes in patients taking cannabidiol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as minor. Cannabidiol and Sofosbuvir-velpatasvir-voxilaprevir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol can inhibit several CYP enzymes and may modestly raise exposure to velpatasvir and voxilaprevir. The expected clinical effect is small, but exposure to the antivirals could increase slightly.
How serious is the interaction between Cannabidiol and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for adverse effects of the antiviral combination such as headache, fatigue and gastrointestinal upset, and for liver enzyme changes in patients taking cannabidiol.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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