Drug interactions
Cannabidiol + Tizanidine
Severity: Moderate
Cannabidiol and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine is a sensitive CYP1A2 substrate and cannabidiol may alter CYP1A2 activity, so tizanidine exposure could change unpredictably. Higher exposure would increase hypotension and sedation. Cannabidiol also has sedative effects of its own.
What this interaction means in plain words
Cannabidiol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Tizanidine belongs to Musculoskeletal.
Why it happens
Cannabidiol may inhibit or induce CYP1A2, altering tizanidine clearance, plus additive sedation.
What to do
Monitor blood pressure, heart rate and sedation when cannabidiol is started or changed and reduce the tizanidine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Tizanidine?
MediHelp rates the interaction as moderate. Cannabidiol and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine is a sensitive CYP1A2 substrate and cannabidiol may alter CYP1A2 activity, so tizanidine exposure could change unpredictably. Higher exposure would increase hypotension and sedation. Cannabidiol also has sedative effects of its own.
How serious is the interaction between Cannabidiol and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and sedation when cannabidiol is started or changed and reduce the tizanidine dose if adverse effects appear.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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