Drug interactions
Cannabidiol + Torsemide
Severity: Minor
Cannabidiol and Torsemide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may inhibit CYP2C9, which metabolizes torsemide. Torsemide levels could rise modestly and increase diuresis and electrolyte disturbance.
What this interaction means in plain words
Cannabidiol and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Torsemide belongs to Cardiovascular.
Why it happens
Inhibition of CYP2C9-mediated torsemide metabolism by cannabidiol.
What to do
Monitor volume status, blood pressure and electrolytes after starting cannabidiol, and lower the torsemide dose if excessive diuresis occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Torsemide
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Torsemide?
MediHelp rates the interaction as minor. Cannabidiol and Torsemide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol may inhibit CYP2C9, which metabolizes torsemide. Torsemide levels could rise modestly and increase diuresis and electrolyte disturbance.
How serious is the interaction between Cannabidiol and Torsemide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor volume status, blood pressure and electrolytes after starting cannabidiol, and lower the torsemide dose if excessive diuresis occurs.
What other medicines interact with Torsemide?
MediHelp also lists interactions of Torsemide with, for example, Amikacin, Amiodarone, Carbenoxolone. The full list is on the Torsemide page.
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