Drug interactions
Cannabidiol + Voriconazole
Severity: Moderate
Cannabidiol and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol is metabolized by CYP3A4 and CYP2C19, both inhibited by voriconazole, so cannabidiol exposure may rise with more sedation, somnolence and adverse effects. Cannabidiol may also inhibit CYP2C19 and increase voriconazole levels.
What this interaction means in plain words
Cannabidiol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP3A4 and CYP2C19, reducing cannabidiol clearance; cannabidiol may inhibit CYP2C19-mediated voriconazole metabolism.
What to do
Consider reducing the cannabidiol dose and monitor for sedation, and for liver enzyme elevations and voriconazole toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Voriconazole?
MediHelp rates the interaction as moderate. Cannabidiol and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol is metabolized by CYP3A4 and CYP2C19, both inhibited by voriconazole, so cannabidiol exposure may rise with more sedation, somnolence and adverse effects. Cannabidiol may also inhibit CYP2C19 and increase voriconazole levels.
How serious is the interaction between Cannabidiol and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the cannabidiol dose and monitor for sedation, and for liver enzyme elevations and voriconazole toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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