Drug interactions
Capecitabine + Dalteparin
Severity: Moderate
Capecitabine and Dalteparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine can cause thrombocytopenia and, through its interaction with vitamin K antagonists, altered coagulation. With dalteparin there may be added bleeding risk, mainly when platelet counts fall.
What this interaction means in plain words
Capecitabine and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Dalteparin belongs to Cardiovascular.
Why it happens
Additive bleeding risk from capecitabine-related myelosuppression and thrombocytopenia combined with dalteparin anticoagulation; no direct pharmacokinetic interaction is established.
What to do
Check platelet counts regularly and monitor for bleeding. Reduce or hold dalteparin if platelets drop substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Dalteparin?
MediHelp rates the interaction as moderate. Capecitabine and Dalteparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine can cause thrombocytopenia and, through its interaction with vitamin K antagonists, altered coagulation. With dalteparin there may be added bleeding risk, mainly when platelet counts fall.
How serious is the interaction between Capecitabine and Dalteparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check platelet counts regularly and monitor for bleeding. Reduce or hold dalteparin if platelets drop substantially.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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