Drug interactions
Capecitabine + Dronabinol
Severity: Minor
Capecitabine and Dronabinol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is cleared by CYP2C9, and capecitabine, through fluorouracil, may reduce CYP2C9 activity. Higher dronabinol exposure could cause more drowsiness, dizziness or tachycardia.
What this interaction means in plain words
Capecitabine and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Capecitabine belongs to Oncology; Dronabinol belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP2C9 metabolism of dronabinol; the interaction is predicted rather than clearly demonstrated.
What to do
Monitor for excessive sedation, cognitive effects and tachycardia. Reduce the dronabinol dose if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Capecitabine
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Capecitabine with Dronabinol?
MediHelp rates the interaction as minor. Capecitabine and Dronabinol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronabinol is cleared by CYP2C9, and capecitabine, through fluorouracil, may reduce CYP2C9 activity. Higher dronabinol exposure could cause more drowsiness, dizziness or tachycardia.
How serious is the interaction between Capecitabine and Dronabinol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, cognitive effects and tachycardia. Reduce the dronabinol dose if these occur.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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