Drug interactions
Capecitabine + Fondaparinux
Severity: Moderate
Capecitabine and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine can cause myelosuppression with thrombocytopenia, which adds to the bleeding tendency of an anticoagulant. Capecitabine also strongly potentiates warfarin, but a direct effect on fondaparinux is not established.
What this interaction means in plain words
Capecitabine and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Fondaparinux belongs to Cardiovascular.
Why it happens
Mainly additive bleeding risk from chemotherapy-related thrombocytopenia; no direct pharmacokinetic interaction is established.
What to do
Monitor platelet counts and watch for bleeding during combined therapy. Hold or reduce anticoagulation if platelets fall markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capecitabine and Fondaparinux, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Fondaparinux?
MediHelp rates the interaction as moderate. Capecitabine and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine can cause myelosuppression with thrombocytopenia, which adds to the bleeding tendency of an anticoagulant. Capecitabine also strongly potentiates warfarin, but a direct effect on fondaparinux is not established.
How serious is the interaction between Capecitabine and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and watch for bleeding during combined therapy. Hold or reduce anticoagulation if platelets fall markedly.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
