Drug interactions
Capecitabine + Omeprazole
Severity: Moderate
Capecitabine and Omeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression has been associated in retrospective data with poorer outcomes in patients taking capecitabine, possibly through reduced absorption. The evidence is inconsistent and pharmacokinetic studies have not confirmed a clear effect.
What this interaction means in plain words
Capecitabine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH may impair capecitabine tablet dissolution; the mechanism is not firmly established.
What to do
Avoid unnecessary PPI use in capecitabine patients; if acid suppression is needed, consider an H2 blocker or review the indication.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Omeprazole?
MediHelp rates the interaction as moderate. Capecitabine and Omeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Acid suppression has been associated in retrospective data with poorer outcomes in patients taking capecitabine, possibly through reduced absorption. The evidence is inconsistent and pharmacokinetic studies have not confirmed a clear effect.
How serious is the interaction between Capecitabine and Omeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary PPI use in capecitabine patients; if acid suppression is needed, consider an H2 blocker or review the indication.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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